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icspecies.Campechecontains134species(66.66%),distributedacross96generaand43families.Notably,46.26%ofthespecies(62species)belongtotheMexicanregion,with8species(12.90%)exclusivetoCampeche.Theresearchrevealedthat27.90%ofthefamiliesand19.79%ofthegenerapresentinthestatehebeenthesubjectofpreviousscientificstudiesregardingtheiruseaspesticides.ThemostextensivelystudiedfamilieswereEuphorbiaceaeandFabaceae.However,thereisanotablelackofresearchonendemicplantsfromtheYucatánPeninsula,underscoringtheneedforincreasedattentiontothesespecies.Theidentifiedgeneraandfamiliescontainchemicalcompoundswithactivityainstsignificantpests,demonstratingsubstantialpotentialforthedevelopmentofnaturalpesticides.Fullarticle(ThisarticlebelongstotheSectionPlantSystematics,Taxonomy,NomenclatureandClassification)9658;9660;ShowFiguresFigure1attachmentSupplementarymaterial:SupplementaryFile1(ZIP,933KiB)17pes,4858KiB OpenAccessArticlePlasma-TreatedWaterRetardsPellicle-likeBiofilmFormationofBacillussubtilisbyThomasWeihe,JanWallis,MareikeMeister,JörgEhlbeckandUtaSchnabelMicrobiol.Res.2024,15(4),2726-2742;doi.org/10.3390/microbiolres(registering DOI)-22Dec2024AbstractPlasma-treatedwater(PTW)recentlyenteredscienceasasanitizingent,whichpossessthecapabilityforon-demandproduction.Itoffersinterestingpossibilitiesforsustainableandresource-singapplicationsinhealthcareandfoodproduction.ThepresentstudymonitorstheimpactofPTWonsuspendedcellsbefore[...]Readmore.Plasma-treatedwater(PTW)recentlyenteredscienceasasanitizingent,whichpossessthecapabilityforon-demandproduction.Itoffersinterestingpossibilitiesforsustainableandresource-singapplicationsinhealthcareandfoodproduction.ThepresentstudymonitorstheimpactofPTWonsuspendedcellsbeforethebiofilmformationoftheputrefactivebacteriumB.subtilis.Lightandelectronmicroscopeimingcapturesthematuringofgrowingbiofilmswithinthefirst24h.Microbiologicalassays(proliferation,LIVE/DEAD,andXTT),whichmirrortheproliferationofthebacterium,themetabolicactivity,andtheintegrityofthecellmembrane,underpinningthemetabolicresponseofstill-suspendedcells.B.subtiliscellswithoutanytreatmentbuilduparesistivebiofilmwithinthe24h.Cellsthatremaininthesupernatantpredominantlyappearasmonomersordimers.TreatedB.subtiliscellshehamperedbiofilmformationandwerenotabletobuildupaconfluentgrowingbiofilmwithinthefirst24h.Moreover,themicroscopicobservationofPTW-treatedsuspensionshowedcellulargregateswithanunusuallyhighconnectivityoftheindividualcells.ThefindingssuggestthiscellularreactionasacountermeasureainsttheadverseimpactofPTWtreatment.TheexperimentsshowtheadverseimpactofPTWonB.subtilis–biofilmformationandthephenomenologicalreactionofB.subtilis.Fullarticle9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure4Cont.---Figure5---Figure6---Figure711pes,1886KiB OpenAccessArticleEvaluationofInternalFitinCustom-MadePostsandCoresFabricatedwithFullyDigitalVersusConventionalTechniquesbyEricJensenandSharielSayardoustJ.Funct.Biomater.2024,15(12),389;doi.org/10.3390/jfb(registering DOI)-22Dec2024AbstractObjective:Thisstudyaimedtoassessandcomparetheinternalfitofcustom-madepostsandcoresfabricatedusingdigitalimpressions(DI)andconventionalvinylpolysiloxane(VPS)impressionsinrestorativedentistry.MaterialsandMethods:Atypodonttoothmodel,simulatingtheanatomyoftheroot[...]Readmore.Objective:Thisstudyaimedtoassessandcomparetheinternalfitofcustom-madepostsandcoresfabricatedusingdigitalimpressions(DI)andconventionalvinylpolysiloxane(VPS)impressionsinrestorativedentistry.MaterialsandMethods:Atypodonttoothmodel,simulatingtheanatomyoftherootcanalofacentralincisor,wasutilizedforthestudy.Twogroupswereformed,GroupAandGroupB,andeachgroupprovidedatotalof18impressionsoftwotypes:DIsandVPSimpressions.InGroupA,postsandcores(PCs)werefabricatedusingSelectiveLaserMelting(SLM)fromtheDIs.Meanwhile,inGroupB,conventionallycast(CC)PCswerecreatedfromtheVPSimpressions.Siliconereplicasoftheinternalsurfaceswereproduced,andmeasurementsweremadeatsevendifferentpointsforeachgroup.Astatisticalanalysiswasperformedtoassessthedifferencesininternalfitbetweenthetwoimpressiontechniques.Results:TheresultsrevealedastatisticallysignificantdifferenceinmeaninternalfitbetweenGroupA(DIandSLM)andGroupB(VPSandCC),withGroupAexhibitingameaninternalfitof182.6µmandGroupBshowingameanof205.9µm.Whilebothgroupsdemonstratedconsiderablevariabilityininternalfitmeasurements,thedigitalimpressiontechniqueshowedpromiseforachievingsuperiorinternalfit,withasignificantlygreaterfitformeasuringpointsonsidesandthemostapicalpartofthepostforGroupA.Variationswereobservedacrossdifferentmeasuringpoints,emphasizingtheimpactofimpressiontechniqueonspecificregionswithinthetooth.Conclusion:ThisstudycontributestothegrowingbodyofknowledgeindigitaldentistrybyhighlightingthepotentialbenefitsofDIsinachievingasuperiorinternalfitforcustom-madePCs.Cliniciansmayconsidertheadvantesofdigitaltechniquestoenhancetheprecisionoftheirrestorativeprocedures,althoughfurtherresearchiswarrantedtoevaluatetheclinicalimpactofthesefindings.Fullarticle(ThisarticlebelongstotheSectionDentalBiomaterials)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure3Cont.21pes,KiB OpenAccessArticleSignificantWeHeightRetrievalinTropicalCycloneConditionsUsingCYGNSSDatabyXiangyangHan,XianweiWang,ZhiHeandJinhuaWuRemoteSens.2024,16(24),4782;doi.org/10.3390/rs(registering DOI)-22Dec2024AbstractTheretrievalofglobalsignificantweheight(SWH)dataiscrucialformaritimenigation,aquaculturesafety,andoceanographicresearch.LeveringthehightemporalresolutionandspatialcovereofCycloneGlobalNigationSatelliteSystem(CYGNSS)data,machinelearningmodelsheshownpromiseinSWH[...]Readmore.Theretrievalofglobalsignificantweheight(SWH)dataiscrucialformaritimenigation,aquaculturesafety,andoceanographicresearch.LeveringthehightemporalresolutionandspatialcovereofCycloneGlobalNigationSatelliteSystem(CYGNSS)data,machinelearningmodelsheshownpromiseinSWHretrieval.However,existingmodelsstrugglewithaccuracyunderhigh-SWHconditionsanddiscardasignificantnumberofsuchobservationsduetolowquality,whichlimitstheireffectivenessinglobalSWHretrieval,particularlyformonitoringtropicalcyclone(TC)events.Toaddressthis,thisstudyproposesadailyglobalSWHretrievalframeworkthroughtheenhancedeXtremeGradientBoostingmodel(XGBoost-SC),whichincorporatesCumulativeDistributionFunction(CDF)matchingtointroducepriordistributioninformationandreduceerrorsforSWHvaluesexceeding3m.Anenhancedlossfunctionisemployedtoimproveaccuracyandmitigatethedistributionbiasinlow-SWHretrievalinducedbyCDFmatching.TheresultsweretestedoveronemillionsamplepointsandvalidatedainsttheEuropeanCentreforMedium-RangeWeatherForecasts(ECMWF)SWHproduct.WiththehelpofCDFmatching,XGBoost-SCoutperformedallmodels,significantlyreducingRMSEandbiaswhileimprovingtheretrievalcapabilityforhighSWHs.ForSWHvaluesbetween3–6m,theRMSEandbiaswere0.94mand−0.44m,andforvaluesabove6m,theywere2.79mand−2.0m.TheenhancedperformanceofXGBoost-SCforlargeSWHswasfurtherconfirmedinTCconditionsovertheWesternNorthPacificandintheWesternAtlanticOcean.Thisstudyprovidesareferenceforlarge-scaleSWHretrieval,particularlyunderTCconditions.Fullarticle(ThisarticlebelongstotheSpecialIssueLatestAdvancesandApplicationintheGNSS-RField)10pes,5172KiB OpenAccessCaseReportSuccessfulLaparoscopy-AssistedExtirpationofBurkitt’sLymphomaCausingIntestinalObstructionina17-Year-OldBoybyZoltánDerzsi,ZsoltBara,EmőkeHorváth,GabrielSerac,RăzvanMărginean,RékaSólyom,EvelynKovácsandHoreaGozarJ.Clin.Med.2024,13(24),7834;doi.org/10.3390/jcm(registering DOI)-22Dec2024AbstractBackground:ChildhoodextranodalB-cellnon-Hodgkin’slymphomasareoftencausedbyBurkitt’slymphoma(BL).Treatmentusuallyinvolvesintensivepolychemotherapy,andrecentprospectivetrialsshowsignificantlyimprovedoutcomes.Surgeryprimarilyinvolvesconductingbiopsies;ablativeinterventionsarenotrecommended.However,incasesofseverepresentation,such[...]Readmore.Background:ChildhoodextranodalB-cellnon-Hodgkin’slymphomasareoftencausedbyBurkitt’slymphoma(BL).Treatmentusuallyinvolvesintensivepolychemotherapy,andrecentprospectivetrialsshowsignificantlyimprovedoutcomes.Surgeryprimarilyinvolvesconductingbiopsies;ablativeinterventionsarenotrecommended.However,incasesofseverepresentation,suchasanacuteabdomen,emergencysurgerymaybenecessary.Methods:Wepresentthecaseofa17-year-oldboywhounderwentemergencysurgeryduetointestinalobstructioncausedbyatumormass.Anexploratorylaparoscopywasperformedduetoabdominalwallinfiltrates,andalargeintraabdominalmasswasdiscoveredintheileocaecalregion.Thetumorandtumorinfiltratesweresuccessfullyremovedenblocinaminimallyinvasivelaparoscopy-assistedfashion.Results:Thepostoperativecoursewasforable,andchemotherapywasstarted.HistopathologyconfirmedthedinosisofBL.Follow-upexaminations,includingapositronemissiontomography(PET)scan,showednotumorrecurrence.Morethantwoyearslater,thepatientremainsasymptomaticwithnegativePETscans.Conclusions:Laparoscopy-assistedremovalcanbeusefulforpediatricsolidabdominaltumorswithabdominalwallinfiltratesthatcauseobstruction.Surgeonsmustassessindicationsandproceduresbasedonimingandfindingsduringemergencyinterventions.TheroleofablativeMISinpediatricBLislimited.Fullarticle(ThisarticlebelongstotheSpecialIssueChallengesinMinimallyInvasiveColorectalandAbdominalWallSurgery)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure414pes,7871KiB OpenAccessArticleFailureandPermeabilityCharacteristicsofCoalPillarinCloselyCoalSeamsGobUnderMultipleMiningbyHuiQiao,SongLiu,LeiDong,PinkunGuoandRuifengGaoProcesses2024,12(12),2934;doi.org/10.3390/pr(registering DOI)-22Dec2024AbstractCoalpillarsareloadedandunloadedrepeatedlywhenmining,whichleadtofracturesinthecoalclose,open,generateandexpand.Asaresult,thepermeabilityofcoalischanged.Thehighpermeabilityfracturesincoalandrockbetweentheuppergobsand[...]Readmore.Coalpillarsareloadedandunloadedrepeatedlywhenmining,whichleadtofracturesinthecoalclose,open,generateandexpand.Asaresult,thepermeabilityofcoalischanged.Thehighpermeabilityfracturesincoalandrockbetweentheuppergobsandthelowerworkingfacesarethemainchannelsforfreshairenteringtheuppergob,whichcouldinducespontaneouscombustionofcoalingob.Toidentifyingtheairleakechannels,multipleminingofcloselycoalseamswasnumericallyconductedwiththreeworkingfacelayouts.Thefailureandpermeabilitycharacteristicofcoalpillarincloselycoalseamsgobundermultipleminingwereobtainedandanalyzed.Whentheworkingfacesaremined,theverticalstressandhorizontalstressoftheuppercoalpillaringobloadandunloadsynchronouslyinallthreeworkingfacelayouts.Thelaterallydirectedhorizontalstresscouldunloadtozeroduetonoconfineonthelateralsideofcoalpillar.Thestressinthemiddleofuppercoalpillarloadscontinuouslyuntilthelowerworkingfaceismined.Whenthelowercoalseamworkingfaceismined,thecoalandrockbetweentheupperandlowercoalseamsdameinshearandtension.Whenthelowercoalseamworkingfaceisstgeredfromtheuppercoalseamworkingface,thepermeabilityofthecoalandrockpillarincreasesmorethantimesduetotensiondameofthecoalandrockpillar.Asaresult,thecoalandrockpillaristhemainchannelforfreshairflowingintotheuppergob.Thehighpermeabilitycoalpillarprovidesforableconditionsforspontaneouscombustionofcoalingob.Fullarticle(ThisarticlebelongstotheSpecialIssueExploration,ExploitationandUtilizationofCoalandGasResources,2ndEdition)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure6---Figure7---Figure8---Figure9---Figure10---Figure11---Figure12---Figure13---Figure14---Figure15---Figure1621pes,809KiB OpenAccessReviewChildhood-OnsetANCA-AssociatedVasculitis:FromGeneticStudiestoAdvancesinPathogenesis,ClassificationandNovelTherapeuticApproachesbyLichingYeo,AsmaNaheed,ChantelleRichardsandCozianaCiurtinInt.J.Mol.Sci.2024,25(24),;doi.org/10.3390/ijms4(registering DOI)-22Dec2024AbstractChildhood-onsetantineutrophilcytoplasmicantibodies(ANCA)-associatedvasculitis(A)representsaheterogeneousgroupofmulti-systemautoimmuneconditionsassociatedwithchronicinflammation,characteristicallyaffectingsmallbloodvessels,leadingtovariousorganandsystemmanifestations.Althoughrareinpaediatricpopulations,Aposeschallengesinearlyrecognition,dinosis[...]Readmore.Childhood-onsetantineutrophilcytoplasmicantibodies(ANCA)-associatedvasculitis(A)representsaheterogeneousgroupofmulti-systemautoimmuneconditionsassociatedwithchronicinflammation,characteristicallyaffectingsmallbloodvessels,leadingtovariousorganandsystemmanifestations.Althoughrareinpaediatricpopulations,Aposeschallengesinearlyrecognition,dinosisandmanementofrefractorycases.ThisreviewhighlightsthecharacteristicsofclinicalpresentationandoutcomesofAinchildren,aswellasitscurrentclassificationandprogressachievedinunderstandingthediseasepathogenesis,withafocusonadultandpaediatricgeneticstudies.Furthermore,wediscussthemanementofAinchildren,aswellasnewemergingtherapiesandfutureresearchneeds,whileproposingapotentialalgorithmforachildhood-onset-Atherapeuticapproachbasedonthediseasephenotype.Fullarticle(ThisarticlebelongstotheSpecialIssueForwardinVasculitis:GeneticsandBeyond)9658;9660;ShowFiguresFigure125pes,5477KiB OpenAccessArticleDual-BranchFeatureGeneralizationMethodforAUVNear-FieldExplorationofHydrothermalAreasbyYihuiLiu,GuofangChen,YufeiXu,LeiWanandZiyangZhangJ.Mar.Sci.Eng.2024,12(12),2359;doi.org/10.3390/jmse(registering DOI)-22Dec2024AbstractThesimultaneouslocalizationandmapping(SLAM)techniqueprovideslong-termnear-seafloornigationforautonomousunderwatervehicles(AUVs).However,thestabilityofdescriptorsgeneratedbyinterestpointdetectorsremainsachallengeinthehydrothermalenvironment.Thispaperproposesadual-branchfeaturegeneralizationmethod,incorporatingvolumetric[...]Readmore.Thesimultaneouslocalizationandmapping(SLAM)techniqueprovideslong-termnear-seafloornigationforautonomousunderwatervehicles(AUVs).However,thestabilityofdescriptorsgeneratedbyinterestpointdetectorsremainsachallengeinthehydrothermalenvironment.Thispaperproposesadual-branchfeaturegeneralizationmethod,incorporatingvolumetricdensityandcolordistributionforenhancedrobustness.Themethodutilizesshareddescriptorsandafeatureconfidencemechanism,combiningneuralradiancefieldswithGaussiansplattingmodels,ensuringfastandaccuratefeaturegeneralization.Theproposedapproachimprovesrecallwhilemaintainingmatchingaccuracy,ensuringstabilityandrobustnessinfeaturematching.Thismethodachievesstableandreliablefeaturematchinginasimulatedhydrothermalenvironment.Fullarticle(ThisarticlebelongstotheSectionOceanEngineering)24pes,KiB OpenAccessArticleThermalManementofCubesatSubsystemElectronicsbyKacperKuta,GrzegorzNowakandIwonaNowakEnergies2024,17(24),6462;doi.org/10.3390/en(registering DOI)-22Dec2024AbstractThetemperaturefieldofanelectronicopticalinstrumentcanaffecttheimequalityrealisedbytheinstrumentand,inextremecases,leadtodame.Thisisparticularlytrueforinstrumentsoperatinginharshenvironmentssuchasspace.Thehyperspectralimingopticalinstrument(OI)[...]Readmore.Thetemperaturefieldofanelectronicopticalinstrumentcanaffecttheimequalityrealisedbytheinstrumentand,inextremecases,leadtodame.Thisisparticularlytrueforinstrumentsoperatinginharshenvironmentssuchasspace.Thehyperspectralimingopticalinstrument(OI)designedfortheIntuition-1(I-1)nanosatellite,currentlyinlowEarthorbit,hasbeensubjectedtoanumericalanalysisofitsthermalstateunderdifferentoperatingconditions,andsomepreliminaryexperimentaltestshebeencarriedouttodeterminethemaximumoperatingtemperaturesofitssensitivecomponentsandtheriskofthermaldame.ThisworkwaspartofatestingcampaignpriortothedeploymentofIntuition-1.Threeoperationalcaseswereanalysed:(1)behiourintheEarth’satmosphericconditionswhentheOIispointedattheSun,(2)theendofthede-tumblingprocessinorbitwiththeSuncrossingthedionaloftheOI’sfieldofview,and(3)identificationofthemaximumpossiblenumberofconsecutiveEarthimingcyclesinorbit.TheultimategoalofthisworkwastovalidatethenumericalapproachusedforthesecasesandtodeepentheunderstandingofthethermalsafetyoftheCMOSimesensorplacedintheOI.Forthesecases,transientthermalfieldanalyseswereperformedfortheOItodeterminethetemperaturedistributionanditsvariabilityinthemostthermallysensitiveCMOSimesensor.ThecomponentsoftheOIanditsoverallstructurewereexperimentallytested,andtheresultswereusedtovalidatethenumericalmodels.Thestudyshowedthatthebuilt-intemperaturesensordoesnotalwaysreflecttheactualCMOStemperature,andinsomeextremecasesthecurrenttemperaturemonitoringdoesnotensureitssafeoperation.Fullarticle(ThisarticlebelongstotheSpecialIssueHeatTransferandThermoelectricGenerator)14pes,2447KiB OpenAccessArticleStrawReturningwithDecompositionentEnhancedRiceYieldandDecreasedYield-ScaledN2OEmissionsinTropicalPaddyFieldsbyLongweiMeng,QiqianLu,TianLin,LuDong,XiaochenWu,YixiuZhuo,AnfuYang,QilinZhuandLeiMengronomy2024,14(12),3060;doi.org/10.3390/ronomy(registering DOI)-22Dec2024AbstractStrawreturning(R)combinedwiththeapplicationofadecompositionent(RD)canincreasecropyieldandsoilcarbon(C)store.However,theeffectofRDonsoilnitrousoxide(N2O)emissionsintropicalareasremainspoorlyunderstood.Inthisstudy,[...]Readmore.Strawreturning(R)combinedwiththeapplicationofadecompositionent(RD)canincreasecropyieldandsoilcarbon(C)store.However,theeffectofRDonsoilnitrousoxide(N2O)emissionsintropicalareasremainspoorlyunderstood.Inthisstudy,aninsituexperimentwasperformedunderdifferentwatermanementstrategies(long-termfloodingoralternatewettinganddrying)withtheRandRDtreatmentstoevaluatesoilN2Oemissionsandriceyield.TheSOCandTNcontentsweresignificantlylowerundertheRDtreatmentthanundertheRtreatment.TheRtreatmentsignificantlyincreasedriceyield;however,theyieldwasfurthersignificantlyincreasedundertheRDtreatment.ThesoilN2Oemissionsandyield-scaledN2OemissionswerehigherundertheRtreatmentthanundertheno-straw-returningtreatment.However,theRDtreatmentgreatlyreducedsoilN2Oemissionsandyield-scaledN2OemissionsundervariouswatermanementstrategiescomparedwiththoseundertheRtreatment.Moreover,yield-scaledN2OemissionswerelowerintheRDtreatmentthaninthecontrol.ThesoilN2Oemissionsandyield-scaledN2Oemissionsweredistinctlyhigherunderalternatewettinganddryingthanunderlong-termflooding.Ourresultsindicatedthatlong-termfloodingandstrawreturningwithdecompositionentscaneffectivelyincreasericeyieldandreducesoilN2Oemissionsintropicalareas.Fullarticle(ThisarticlebelongstotheSectionInnovativeCroppingSystems)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure622pes,KiB OpenAccessArticleTheUseofRecycledCeramicsandAshfromMunicipalSeweSludgeasConcreteFillersbyJacekSzulej,PawełOgrodnik,FilipChyliński,BeataKlimek,AleksandraPowęzka,MariuszŻółtowskiandAdamBaryłkaSustainability2024,16(24),;doi.org/10.3390/su1(registering DOI)-22Dec2024AbstractThemainaimoftheresearchwastoevaluatethefeasibilityofusingrecycledceramicsandashfrommunicipalsewesludgeasconcretefillers.Aspartofthestudy,standardcylindricalandcubicsampleswereinvestigated.Thesamplesconsistedofwasteceramicgregate[...]Readmore.Themainaimoftheresearchwastoevaluatethefeasibilityofusingrecycledceramicsandashfrommunicipalsewesludgeasconcretefillers.Aspartofthestudy,standardcylindricalandcubicsampleswereinvestigated.Thesamplesconsistedofwasteceramicgregatefractions0–4mmand4–8mm,whichweresourcedfromusedproductsmanufacturedbyasanitaryfittingsfactory,aswellasashfromoneofthePolishsewetreatmentplants.Thechemicalcompositionandmorphologyofrecycledmaterialsusedtoproduceconcretewereexamined.Theresearchitselffocusedondeterminingthestrengthpropertiesoftheproducedcompositesunderbothnormalconditionsandafterinitialheattreatment.Microstructuraltestsoftheproducedcompositeswerealsocarriedout.Theresultsdemonstratedthatselectedrecycledmaterialscansuccessfullyreplacematerialspreviouslyusedinconcreteproduction.Theobtainedstrengthresultsdonotdiffersignificantlyfromthestrengthofconcretemadeoftraditionalmaterials.Researchhasconfirmedthepossibilityofusingwastematerialsasconcretefillers.Fullarticle(ThisarticlebelongstotheSectionEnergySustainability)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure6---Figure7---Figure8---Figure9---Figure10---Figure11---Figure12---Figure13---Figure14---Figure15---Figure16---Figure17---Figure17Cont.---Figure18attachmentSupplementarymaterial:SupplementaryFile1(ZIP,14KiB)17pes,8450KiB OpenAccessArticleMaxEnt-BasedHabitatSuitabilityAssessmentforVacciniummandarinorum:ExploringIndustrialCultivationOpportunitiesbyXuxuBao,PengZhou,MinZhang,YanmingFangandQiangZhangForests2024,15(12),2254;doi.org/10.3390/f(registering DOI)-22Dec2024AbstractVacciniummandarinorumDiels,awildblueberryspeciesdistributedinthesouthoftheYangtzeRiverinChina,holdssignificantecologicalandcommercialvalue.Understandingitspotentialdistributionandresponsetoclimatechangeiscrucialforeffectiveresourceutilizationandscientificintroduction.Byusing[...]Readmore.VacciniummandarinorumDiels,awildblueberryspeciesdistributedinthesouthoftheYangtzeRiverinChina,holdssignificantecologicalandcommercialvalue.Understandingitspotentialdistributionandresponsetoclimatechangeiscrucialforeffectiveresourceutilizationandscientificintroduction.ByusingtheMaximumEntropy(MaxEnt)model,weevaluatedV.mandarinorum’spotentialdistributionundercurrent(1970–2000)andfutureclimatechangescenarios(2041–2060,2061–2080,and2081–2100)basedon216moderndistributionrecordsandsevenbioclimaticvariables.TheresultsshowedthattheMaxEntmodelcouldeffectivelysimulatethehistoricaldistributionandsuitabilitydegreeofV.mandarinorum.Thetoptwomajorenvironmentalvariableswereprecipitationofthedriestquarterandannualprecipitation,consideringtheircontributionratesof61.3%and23.4%,respectively.Currently,thehighsuitabilityareasweremainlyconcentratedincentralandnorthernJiangxiprovince,centralandsouthernZhejiangprovince,southernAnhuiprovince,centralandnorthernFujianprovince,andtheborderareasofHunanandGuangxiprovinces,covering21.5%ofthetotalsuitablearea.Futureprojectionsindicatethathabitatwillshifttohigherlatitudesandaltitudesandthathabitatqualitywilldecline.StrategiesarerequiredtoprotectcurrentV.mandarinorumpopulationsandtheirhabitats.Thestudyresultscouldprovideanimportanttheoreticalreferencefortheoptimizationofplantingdistributionandensurethesustainableproductionoftheblueberryindustry.Fullarticle(ThisarticlebelongstotheSectionForestEcologyandManement)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure6attachmentSupplementarymaterial:SupplementaryFile1(ZIP,807KiB)16pes,2650KiB OpenAccessArticleInsulinSensitivityControlsActivityofPathogenicCD4+TCellsinRheumatoidArthritisbyMalinC.Erlandsson,EricMalmhäll-Bah,VenkataranChandrasekaran,KarinM.E.Andersson,LisaM.Nilsson,SofiaTöyräSilfverswärd,RillePulleritsandMariaI.BokarewaCells2024,13(24),2124;doi.org/10.3390/cells(registering DOI)-22Dec2024AbstractHyperinsulinemiaconnectsobesity,andapoorlipidprofile,withtype2diabetes(T2D).Here,weinvestigatedconsequencesofinsulinexposureforTcellfunctioninthecanonicalautoimmunityofrheumatoidarthritis(RA).Weobservedthatinsulinlevelscorrelatedwiththeglycolyticindexof[...]Readmore.Hyperinsulinemiaconnectsobesity,andapoorlipidprofile,withtype2diabetes(T2D).Here,weinvestigatedconsequencesofinsulinexposureforTcellfunctioninthecanonicalautoimmunityofrheumatoidarthritis(RA).WeobservedthatinsulinlevelscorrelatedwiththeglycolyticindexofCD4+cellsbutsuppressedtranscriptionofinsulinreceptorsubstrates,whichwasinverselyrelatedtoinsulinsensitivity.ThisconnectionbetweeninsulinlevelsandtheglycolyticindexwasnotseeninCD4+cellsofhealthycontrols.ExposureofCD4+cellstoinsulininducedasenescentstaterecognizedbycellcyclearrestandDNAcontentenrichmentmeasuredbyflowcytometry.ItalsoresultedinaccumulationofDNAdamemarkerγH2AX.InsulinsuppressedIFNγproductionandinducedthesenescence-associatedsecretomeinCD4+cellculturesandinpatientswithhyperinsulinemia.InhibitionofJAK-STATsignaling(JAKi)improvedinsulinsignaling,whichactivatedtheglycolyticindexandfacilitatedsenescenceinCD4+cellcultures.TreatmentwithJAKiwasassociatedwithanabundanceofnaïveandrecentthymicemigrantTcellsinthecirculationofRApatients.Thus,weconcludedthatinsulinexertsimmunosuppressiveabilitybyinducingsenescenceandinhibitingIFNγproductioninCD4+cells.JAKipromotesinsulineffectsandsupportseliminationofthepathogenicCD4+cellinRApatients.Fullarticle(ThisarticlebelongstotheSectionCellularMetabolism)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure418pes,318KiB OpenAccessArticleSpinorEquationsofSmarandacheCurvesinE3byZeynepİsabeyoǧlu,TülayErişirandAyşeZeynepAzakMathematics2024,12(24),4022;doi.org/10.3390/math(registering DOI)-22Dec2024AbstractThisstudyexaminesthespinorrepresentationsofTN(tangentandnormal),NB(normalandbinormal),TB(tangentandbinormal)andTNB(tangent,normalandbinormal)–Smarandachecurvesinthree-dimensionalEuclideanspaceE3.SpinorsarecomplexcolumnvectorsandmoveonPaulispin[...]Readmore.ThisstudyexaminesthespinorrepresentationsofTN(tangentandnormal),NB(normalandbinormal),TB(tangentandbinormal)andTNB(tangent,normalandbinormal)–Smarandachecurvesinthree-dimensionalEuclideanspaceE3.SpinorsarecomplexcolumnvectorsandmoveonPaulispinmatrices.IsotropicvectorsintheC3complexvectorspaceformatwo-dimensionalsurfaceintheC2complexspace.Additionally,eachisotropicvectorinC3spacecorrespondstotwovectorsinC2space,calledspinors.Basedonthisinformation,ourgoalistoestablisharelationshipbetweencurvetheoryindifferentialgeometryandspinorspacebymatchingaspinorwithanisotropicvectorandarealvectorgeneratedfromthevectorsoftheFrenet–Serretframeofacurveinthree-dimensionalEuclideanspace.Accordingly,weinitiallyassumetwospinorscorrespondingtotheFrenet–Serretframesofthemaincurveandits(TN,NB,TBandTNB)–Smarandachecurves.Then,weutilizetherelationshipsbetweentheFrenetframesofthesecurvestoexaminetheconnectionsbetweenthetwospinorscorrespondingtothesecurves.Thus,wegivetherelationshipsbetweenspinorscorrespondingtotheseSmarandachecurves.Forthisreason,thisstudycreatesabridgebetweenmathematicsandphysics.Thisstudycanalsoserveasareferencefornewstudiesingeometryandphysicsasageometricinterpretationofaphysicalexpression.Fullarticle(ThisarticlebelongstotheSpecialIssueDifferentialGeometricStructuresandTheirApplications)13pes,6518KiB OpenAccessArticleTowardsRobustSupervisedPectoralMuscleSegmentationinMammographyImesbyParvanehAliniya,MirceaNicolescu,MonicaNicolescuandGeorgeBebisJ.Iming2024,10(12),331;doi.org/10.3390/jiming(registering DOI)-22Dec2024AbstractMammographyimesarethemostcommonlyusedtoolforbreastcancerscreening.Thepresenceofpectoralmuscleinimesforthemediolateralobliqueviewmakesdesigningarobustautomatedbreastcancerdetectionsystemmorechallenging.Mostofthecurrentmethodsforremovingthe[...]Readmore.Mammographyimesarethemostcommonlyusedtoolforbreastcancerscreening.Thepresenceofpectoralmuscleinimesforthemediolateralobliqueviewmakesdesigningarobustautomatedbreastcancerdetectionsystemmorechallenging.Mostofthecurrentmethodsforremovingthepectoralmusclearebasedontraditionalmachinelearningapproaches.Thisispartlyduetothelackofsegmentationmasksofpectoralmuscleinailabledatasets.Inthispaper,weprovidethesegmentationmasksofthepectoralmusclefortheINbreast,MIAS,andCBIS-DDSMdatasets,whichwillenablethedevelopmentofsupervisedmethodsandtheutilizationofdeeplearning.Trainingdeeplearning-basedmodelsusingsegmentationmaskswillalsobeapowerfultoolforremovingpectoralmuscleforunseendata.Totestthevalidityofthisidea,wetrainedAU-NetseparatelyontheINbreastandCBIS-DDSMforthesegmentationofthepectoralmuscle.Weusedcross-datasettestingtoevaluatetheperformanceofthemodelsonanunseendataset.Inaddition,themodelsweretestedonalloftheimesintheMIASdataset.Theexperimentalresultsshowthatcross-datasettestingachievesacomparableperformancetothesame-datasetexperiments.Fullarticle(ThisarticlebelongstotheSpecialIssueImeSegmentationTechniques:CurrentStatusandFutureDirections(2ndEdition))15pes,663KiB OpenAccessArticleThreatstotheDignityofPeoplewithAdvancedIllnessWhoAreTreatedinEmergencyDepartments:AQualitativeStudybyAlbaFernández-Férez,OusmaneBerthe-Kone,GonzaloGranero-Heredia,MatíasCorrea-Casado,MaríadelMarJiménez-Lasserrotte,ÁlvaroMartínez-BordajandiandJoséGranero-MolinaHealthcare2024,12(24),2581;doi.org/10.3390/healthcare(registering DOI)-22Dec2024AbstractBackground:Dignityisakeyelementinend-of-lifecare.Patientswithadvancedillnessattendtheemergencydepartmenttoseeksymptomreliefbutmayfindtheirdignityunderthreatintheseservices.Objective:Thepurposeofthestudywastoexplorethethreatsto[...]Readmore.Background:Dignityisakeyelementinend-of-lifecare.Patientswithadvancedillnessattendtheemergencydepartmenttoseeksymptomreliefbutmayfindtheirdignityunderthreatintheseservices.Objective:Thepurposeofthestudywastoexplorethethreatstodignityperceivedbypeoplewithadvancedillnesseswhoaretreatedinemergencydepartments.Methods:Adescriptivequalitativestudywasdesignedforwhich18patientswithadvancedillnesseswereinterviewedafterbeingseeninanemergencydepartment.ThestudycompliedwiththeprinciplesoftheDeclarationofHelsinkiformedicalresearchinvolvinghumansubjects.Results:Twothemesweredevelopedfromthedataanalysisthatshedlightonhowpatientswithadvancedillnessesperceivethreatstotheirdignitywhenseeninemergencydepartments:(1)“whencarefocusedondinosisandtreatmentlimitsthedignityofthepatientwithadvancedillness”and(2)“thesocialdimensionofdignityinpeoplewithadvancedillnessinemergencydepartments”.Conclusions:Weconcludethatthestructural,organizational,andcarecharacteristicsofemergencydepartmentsmayposeathreattothedignityofpeoplewithadvancedillnesseswhoattendtheemergencydepartment.Familymembers,professionals,andotherpatientscanbothguaranteeandthreatenthedignityofpeoplewithadvancedillnesseswhentheyaretreatedinemergencydepartments.Fullarticle(ThisarticlebelongstotheSpecialIssueNewInsightsintoUnderstudiedPhenomenainHealthcare)9658;9660;ShowFiguresFigure1attachmentSupplementarymaterial:SupplementaryFile1(ZIP,332KiB)26pes,579KiB OpenAccessReviewAIinHepatology:RevolutionizingtheDinosisandManementofLiverDiseasebyShezaMalik,RishiDas,ThanitaThongtan,KathrynThompsonandNaderDboukJ.Clin.Med.2024,13(24),7833;doi.org/10.3390/jcm(registering DOI)-22Dec2024AbstractTheintegrationofartificialintelligence(AI)intohepatologyisrevolutionizingthedinosisandmanementofliverdiseasesamidstarisingglobalburdenofconditionslikemetabolic-associatedsteatoticliverdisease(MASLD).AIharnessesvastdatasetsandcomplexalgorithmstoenhanceclinicaldecisionmakingand[...]Readmore.Theintegrationofartificialintelligence(AI)intohepatologyisrevolutionizingthedinosisandmanementofliverdiseasesamidstarisingglobalburdenofconditionslikemetabolic-associatedsteatoticliverdisease(MASLD).AIharnessesvastdatasetsandcomplexalgorithmstoenhanceclinicaldecisionmakingandpatientoutcomes.AI’sapplicationsinhepatologyspanavarietyofconditions,includingautoimmunehepatitis,primarybiliarycholangitis,primarysclerosingcholangitis,MASLD,hepatitisB,andhepatocellularcarcinoma.Itenablesearlydetection,predictsdiseaseprogression,andsupportsmoreprecisetreatmentstrategies.Despiteitstransformativepotential,challengesremain,includingdataintegration,algorithmtransparency,andcomputationaldemands.ThisreviewexaminesthecurrentstateofAIinhepatology,exploringitsapplications,limitations,andtheopportunitiesitpresentstoenhanceliverhealthandcaredelivery.Fullarticle(ThisarticlebelongstotheSpecialIssueAdvancesinLeveringBigDataforImprovingPatientOutcomesinGastrointestinalandHepatopancreatobiliaryDiseases)9658;9660;ShowFiguresFigure122pes,1070KiB OpenAccessArticleAdditiveManufacturingofaFrost-DetectionResistiveSensorforOptimizingDemandDefrostinRefrigerationSystemsbyMartimLimadeuiar,PedroDinisGasparandPedroDinhodaSilvaSensors2024,24(24),8193;doi.org/10.3390/s(registering DOI)-22Dec2024AbstractThisarticlepresentsthedevelopmentofaresistivefrost-detectionsensorfabricatedusingFusedFilamentFabrication(FFF)withaconductivefilament.Thissensorwasdesignedtoenhancedemand-defrostcontrolinindustrialrefrigerationsystems.Frostaccumulationonevaporatorsurfacesblocksairflowandcreatesathermal[...]Readmore.Thisarticlepresentsthedevelopmentofaresistivefrost-detectionsensorfabricatedusingFusedFilamentFabrication(FFF)withaconductivefilament.Thissensorwasdesignedtoenhancedemand-defrostcontrolinindustrialrefrigerationsystems.Frostaccumulationonevaporatorsurfacesblocksairflowandcreatesathermalinsulatingbarrierthatreducesheatexchangeefficiency,increasingenergyconsumptionandoperationalcosts.Traditionaltimeddefrostingcontrolmethodscanmitigatetheseeffectsbutoftenleadtoinefficienciesduetotheirinabilitytoalignwithactualfrostaccumulation,whichcanvaryaccordingtosystemandenvironmentalconditions.Frost-detectionsensorsaimtosolvethisproblembyactingasatooltosupportdefrostingcontrol.Aseriesoftestswereconductedtoevaluatethesensor’sperformanceindetectingfrostundercontrolledconditionsonaheatexchanger(HX).Thesensorreliablydetectedfrostinallcases,demonstratingitseffectivenessinreal-timefrostdetection.Thesensormeasurementswerevalidatedbycomparisonwithresultsobtainedthroughacomputervisionmethod,confirmingitsreliability.Itwasalsofoundthatthesensorcandetecttemperaturechanges.Thisadvancementinsensortechnologyhighlightsthepotentialofadditivemanufacturingtoprovidecost-effective,customizable,replicable,andcompactsensordesigns,contributingtoimprovedsystemperformanceandenergyefficiencyinrefrigerationsystems.Fullarticle(ThisarticlebelongstotheSectionPhysicalSensors)24pes,4058KiB OpenAccessReviewTargetingofNon-ClassicalHumanLeukocyteAntigensasNovelTherapeuticStrategiesinCancerbyJierDidBenitezFuentes,JorgeBartolomeArcilla,KauzarMohamedMohamed,AlfonsoLopezdeSa,AliciadeLunauilar,KissyGuevara-Hoyer,PabloBallestinMartinez,AntonioDidLazaroSanchez,EdgardoD.Carosella,AlbertoOcañaandSilviaSánchez-RamonCancers2024,16(24),4266;doi.org/10.3390/cancers(registering DOI)-22Dec2024AbstractHumanleukocyteantigens(HLAs)areessentialregulatorsofimmuneresponsesainstcancer,withclassicalHLAswell-documentedfortheirroleintumorrecognitionandimmunesurveillance.Inrecentyears,non-classicalHLAs—includingHLA-E,HLA-F,HLA-G,andHLA-H—heemergedascriticalplayersintheimmunelandscape[...]Readmore.Humanleukocyteantigens(HLAs)areessentialregulatorsofimmuneresponsesainstcancer,withclassicalHLAswell-documentedfortheirroleintumorrecognitionandimmunesurveillance.Inrecentyears,non-classicalHLAs—includingHLA-E,HLA-F,HLA-G,andHLA-H—heemergedascriticalplayersintheimmunelandscapeofcancerduetotheirdiverseandlessconventionalfunctionsinimmunemodulation.Thesemoleculesexhibituniquemechanismsthatenabletumorstoescapeimmunedetection,promotetumorprogression,andcontributetotherapeuticresistance.Thisreviewprovidesacomprehensiveexaminationofthecurrentunderstandingofnon-classicalHLAsinsolidcancers,focusingontheirspecificrolesinshapingthetumormicroenvironmentandinfluencingimmuneresponses.ByanalyzinghowHLA-E,HLA-F,HLA-G,andHLA-Hmodulateinteractionswithimmunecells,suchasTcells,naturalkillercells,andantigen-presentingcells,wehighlightkeypathwaysthroughwhichthesemoleculescontributetoimmuneevasionandmetastasis.Additionally,wereviewpromisingtherapeuticstrategiesaimedattargetingnon-classicalHLAs,includingemergingimmunotherapiesthatcouldpotentiallyenhancecancertreatmentoutcomesbyreversingimmunesuppressionwithintumors.Understandingtheinfluenceofthesenon-classicalHLAsinsolidcancersmayoffernewinsightsintocancerimmunologyandmayleadtothedevelopmentofinnovativeandmoreeffectiveimmunotherapeuticapproaches.Thisreviewunderscorestheimportanceofnon-classicalHLAsaspotentialtherapeutictargets,providinganecessaryfoundationforfuturestudiesintheevolvingfieldofcancerimmunotherapy.Fullarticle(ThisarticlebelongstotheSpecialIssueIdentificationandClinicalApplicationofImmunologicalReceptorsTargetingMutatedAntigensExpressedbySolidTumors (2ndEdition))9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure636pes,8289KiB OpenAccessReviewOntheUseofGreenandBlueLaserSourcesforPowderBedFusion:StateoftheArtReviewforAdditiveManufacturingofCopperandItsAlloysbyMankiratSinghKhandpur,AlbertoGiubilini,LucaIulianoandPaoloMinetolaMetals2024,14(12),1464;doi.org/10.3390/met(registering DOI)-22Dec2024AbstractAdditivemanufacturing(AM)isalayerwiseproductionprocessthatcreatesthree-dimensionalobjectsaccordingtoadigitalmodel.Thistechnologyhasdemonstratedtobeapromisingalternativetoconventionalmanufacturingmethodsforvariousindustrialsectors,suchasaerospace,automotive,biomedical,andenergy.AMoffers[...]Readmore.Additivemanufacturing(AM)isalayerwiseproductionprocessthatcreatesthree-dimensionalobjectsaccordingtoadigitalmodel.Thistechnologyhasdemonstratedtobeapromisingalternativetoconventionalmanufacturingmethodsforvariousindustrialsectors,suchasaerospace,automotive,biomedical,andenergy.AMoffersseveraladvantes,likedesignflexibility,materialefficiency,functionalintegration,andrapidprototyping.Asregardsmetalparts,conventionalAMtechniquesusinginfraredlasersourcesfacesomelimitationsinprocessinghigh-reflectivityandhigh-conductivitymaterialsoralloys,suchasaluminum,copper,gold,andsilver.Thesematerialshelowabsorptionofinfraredradiation,whichresultsinunstableandshallowmeltpools,poorsurfacequality,andhighporosity.Toovercomethesechallenges,greenandbluelasersourceshebeenproposedforAMprocesses.Thisreviewprovidesanoverviewoftherecentdevelopmentsandapplicationsofgreenandbluelasersourcesforpowderbedfusionofcopperanditsalloys,focusingontheeffectsofprocessparametersonthemeltpooldynamics,microstructureformation,andthermalandelectricalpropertiesofthefabricatedparts.ThisreviewalsopresentsthemainapplicationsofAMofcopperanditsalloystogetherwithpotentialopportunitiesforfuturedevelopments.Fullarticle(ThisarticlebelongstotheSpecialIssueDevelopmentofMetallicMaterialLaserAdditiveManufacturing)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure6---Figure7---Figure7Cont.---Figure8---Figure9---Figure10---Figure11---Figure12---Figure13---Figure14---Figure15---Figure16---Figure17---Figure1813pes,4407KiB OpenAccessArticleMolecularDynamicsSimulationoftheCompatibilityBetweenSupercriticalCarbonDioxideandCoatingResinsAssistedbyCo-SolventsbyNanWang,ChenxiaoPei,YuhangZhong,YuqiZhang,XingangLiu,JianyuanHou,YuanYuanandRenxiZhangMaterials2024,17(24),6271;doi.org/10.3390/ma(registering DOI)-22Dec2024AbstractTheuseofsupercriticalcarbondioxide(ScCO2)asareplacementforvolatileorganicsolventsincoatingshasthepotentialtoreduceairpollution.Thispaperpresentsthefindingsofamoleculardynamicssimulationstudyinvestigatingthedissolutionbehiorofpolyvinylidenefluoride[...]Readmore.Theuseofsupercriticalcarbondioxide(ScCO2)asareplacementforvolatileorganicsolventsincoatingshasthepotentialtoreduceairpollution.Thispaperpresentsthefindingsofamoleculardynamicssimulationstudyinvestigatingthedissolutionbehiorofpolyvinylidenefluoride(PVDF)inScCO2assistedbyfiveco-solvents.Onthebasisofsolubilityparameters,interactionbindingenergy,andradialdistributionfunctions,theimpactsoftemperature,pressure,andco-solventsonthecompatibilityofScCO2andPVDFwereinvestigatedatthemicroscopiclevel.Thesimulationresultsdemonstratedthatlow-temperatureandhigh-pressureconditionsfacilitatethedissolutionofPVDFinScCO2,wheretheoptimalconditionsare308.15Kand16MPa.TheenhancementofthesolubilityperformanceofScCO2sloweddownwithincreasingpressure,butwasmoresensitivetochangesintemperature.TheweakattractionbetweenPVDFandScCO2wassynergizedbyvanderWaalsandelectrostaticforces,makingitchallengingtoachievecompleteandhomogeneousmixing.Theuseofco-solventswithstrongpolaritycanenhancethesolventsystem’ssolubility.Ethanoland2-butoxy-1-ethanolheobvioussolubilizingabilitiesduetothehydrogenbonddonors,whichcangeneratehydrogenbondinginteractionswithScCO2,increasethepolarityofthesolventsystem,andpromotethecompatibilityofScCO2withPVDF.Fullarticle9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure6---Figure7---Figure8---Figure914pes,2146KiB OpenAccessArticleDevelopmentofaPredictiveModelforN-DealkylationofAmineContaminantsBasedonMachineLearningMethodsbyShiyangCheng,QihangZhang,HaoMin,WenhuiJiang,JuetingLiu,ChunshengLiuandZehuaWangToxics2024,12(12),931;doi.org/10.3390/toxics(registering DOI)-22Dec2024AbstractAminesarewidespreadenvironmentalpollutantsthatmayposehealthrisks.Specifically,theN-dealkylationofaminesmediatedbycytochromeP450enzymes(P450)couldinfluencetheirmetabolictransformationsafety.However,conventionalexperimentalandcomputationalchemistrymethodsmakeitdifficulttoconducthigh-throughputscreeningofN-dealkylation[...]Readmore.Aminesarewidespreadenvironmentalpollutantsthatmayposehealthrisks.Specifically,theN-dealkylationofaminesmediatedbycytochromeP450enzymes(P450)couldinfluencetheirmetabolictransformationsafety.However,conventionalexperimentalandcomputationalchemistrymethodsmakeitdifficulttoconducthigh-throughputscreeningofN-dealkylationofemergingaminecontaminants.Machinelearninghasbeenwidelyusedtoidentifysourcesofenvironmentalpollutantsandpredicttheirtoxicity.However,itsapplicationinscreeningcriticalbiotransformationpathwaysfororganicpollutantshasbeenrarelyreported.Inthisstudy,wefirstconstructedalargedatasetcomprising286emergingaminepollutantsthroughathoroughsearchofdatabasesandliterature.Then,weappliedfourmachinelearningmethods—randomforest,gradientboostingdecisiontree,extremegradientboosting,andmulti-layerperceptron—todevelopbinaryclassificationmodelsforN-dealkylation.Thesemodelswerebasedonsevencarefullyselectedmoleculardescriptorsthatrepresentreactivity-fitandstructural-fit.Amongthepredictivemodels,theextremegradientboostingshowsthehighestpredictionaccuracyof81.0%.TheSlogP_VSA2descriptoristheprimaryfactorinfluencingpredictionsofN-dealkylationmetabolism.Thenanensemblemodelwasgeneratedthatusesaconsensusstrategytointegratethreedifferentalgorithms,whoseperformanceisgenerallybetterthananysinglealgorithm,withanaccuracyrateof86.2%.Therefore,theclassificationmodeldevelopedinthisworkcanprovidemethodologicalsupportforthehigh-throughputscreeningofN-dealkylationofaminepollutants.Fullarticle24pes,2007KiB OpenAccessArticleGreeningtheGulf:ADeep-DiveintotheSynergyBetweenNaturalResources,InstitutionalQuality,ForeignDirectInvestment,andPathwaystoEnvironmentalSustainabilitybyFengQinandAliImranSustainability2024,16(24),;doi.org/10.3390/su0(registering DOI)-22Dec2024AbstractEnvironmentalqualityisaglobalconcern,especiallyinGulfCooperationCouncil(GCC)countrieswhereabundantmineralresources,economicgrowth,andglobalizationhestrainedtheenvironmentthroughurbanizationandresourceexploitation.Thisstudyexaminestheimpactofglobalization(GLOL),urbanization(URBN),naturalresourceextraction[...]Readmore.Environmentalqualityisaglobalconcern,especiallyinGulfCooperationCouncil(GCC)countrieswhereabundantmineralresources,economicgrowth,andglobalizationhestrainedtheenvironmentthroughurbanizationandresourceexploitation.Thisstudyexaminestheimpactofglobalization(GLOL),urbanization(URBN),naturalresourceextraction(NRER),institutionalquality(INSQ),andforeigndirectinvestment(FDI)onenvironmentalqualityinGCCcountriesfrom1999to2021.Cross-sectionaldependence(CSD)wasassessedusingtheLrangeMultiplier(LM)andcross-dependence(CD)techniques,andstationaritywasconfirmedwiththeLevin–Lin–Chutest.TheAugmentedDickey–Fuller(ADF)co-integrationtestverifiedlong-termrelationships,andPooledMeanGroupAutoregressiveDistributedL(PMG-ARDL)methodologyassessedshort-andlong-termeffects.OurfindingsshowthatFDI,GLOL,andINSQhenegativelong-termimpactsonenvironmentalquality,whileNRERandURBNarebeneficial.Intheshortterm,FDIandINSQimprovegreenquality,whileGLOL,URBN,andNRERhedetrimentaleffects.PolicyrecommendationsincludediscouringFDIinnon-renewableprojects,promotingsustainableFDI,addressingincomeinequalitytoimproveenvironmentalquality,andinvestinginurbandevelopmenttoreduceecologicalfootprints(ECFTs)andenhanceenvironmentalqualityinGCCcountries.Fullarticle9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure521pes,KiB OpenAccessArticleTheEffectofElastomerContentandAnnealingonthePhysicalPropertiesofUpcycledPolyethyleneTerephthalate-MaleatedStyreneEthyleneButyleneStyreneBlendsforAdditiveManufacturingbyDiegoBermudez,StephanieMorenoandDidA.RobersonMaterials2024,17(24),6272;doi.org/10.3390/ma(registering DOI)-22Dec2024AbstractIntheworkpresentedhere,weexploretheupcyclingofpolyethyleneterephthalate(PET)thatwasderivedfromwaterbottles.Thematerialwasgranulatedandextrudedintoafilamentcompatiblewithfusedfilamentfabrication(FFF)additivemanufacturingplatforms.ThreeiterationsofPETcombinedwith[...]Readmore.Intheworkpresentedhere,weexploretheupcyclingofpolyethyleneterephthalate(PET)thatwasderivedfromwaterbottles.Thematerialwasgranulatedandextrudedintoafilamentcompatiblewithfusedfilamentfabrication(FFF)additivemanufacturingplatforms.ThreeiterationsofPETcombinedwithathermoplasticelastomer,styreneethylenebutylenestyrenewithamaleicanhydridegraft(SEBS-g-MA),weremadewith5,10,and20%bymasselastomercontent.Theelastomerandspecificmasspercenteswerechosenbasedonpriorsuccessesinvolvingacrylonitrilebutadienestyrene(ABS),inwhichthemaleicanhydridegraftenabledcompatibilitybetweendifferentmaterials.TherheologicalpropertiesofPETandthePET/SEBSblendswerecharacterizedbythemeltflowindexanddynamicmechanicalanalysis.TheadditionofSEBS-g-MAdidnotheasignificantimpactonmechanicalproperties,asdeterminedbytensileandimpacttesting,wherealltestspecimensweremanufacturedbyFFF.Delaminationofthetensilespecimensconvolutedtheabilitytodiscerndifferencesinthemechanicalproperties,particularly%elongation.Annealingofthespecimensenabledtheobservationoftheeffectofelastomercontentonthemechanicalproperties,particularlyinthecaseofimpacttesting,wheretheimpactstrengthincreasedwiththeincreaseinSEBScontent.However,annealingledtoshrinkeofthespecimens,detractingfromtherealizedbenefitsofthethermalprocess.Scanningelectronmicroscopyofspenttensilespecimensrevealedthat,inthenon-annealedcondition,SEBSformednodulesthatwoulddetachfromthePETmatrixduringthetensiletest,indicatingthatarobustbondwasnotpresent.TheadditionofSEBS-g-MAdidallowforshapememorypropertycharacterization,wheredeformationoftensilespecimensoccurredatroomtemperature.Specimensfromthe20%bymasselastomercontentsamplegroupexhibitedashapefixationratioontheorderof99%andashaperecoveryratioontheorderof80%.Thisworkdemonstratesapotentialwastereductionstrategytotackletheproblemofpolymerwastebyupcyclingdiscardedplasticintoafeedstockmaterialforadditivemanufacturingwithshapememoryproperties.Fullarticle(ThisarticlebelongstotheSectionPolymericMaterials)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure6---Figure7---Figure8---Figure9---Figure10---Figure11---Figure12---Figure13---Figure14---Figure15---Figure16---Figure17---Figure1812pes,1382KiB OpenAccessArticleTheEffectsofAldosteroneonHypertension-AssociatedKidneyInjuryinaTg-hASMouseModelbyHuiyingGu,ZheChen,NicoleDu,SisiYang,YongqiYuandYanshengDuBiology2024,13(12),1084;doi.org/10.3390/biology(registering DOI)-22Dec2024AbstractHypertensionremainsaglobalhealthchallengeduetoitshighprevalenceandassociationwithprematuremorbidityandmortality.Aldosterone,amineralocorticoidhormone,anditsreceptor,themineralocorticoidreceptor(MR),arehighlyimplicatedinhypertensionpathogenesis.Aldosteronesynthaseisthesoleenzymeresponsiblefor[...]Readmore.Hypertensionremainsaglobalhealthchallengeduetoitshighprevalenceandassociationwithprematuremorbidityandmortality.Aldosterone,amineralocorticoidhormone,anditsreceptor,themineralocorticoidreceptor(MR),arehighlyimplicatedinhypertensionpathogenesis.Aldosteronesynthaseisthesoleenzymeresponsibleforproducingaldosteroneinhumans.Weestablishedtransgenicmicecarryingthehumanaldosteronesynthasegene(cyp11B2)andshoweddramaticallyincreasedlevelsofaldosteroneinfemalehemizygotes.High-saltdietspersistentlyincreasedbloodpressureinthesemice,andsalt-inducedhypertensionwassignificantlyamelioratedbyreducingaldosteronelevelsviaanaldosteronesynthaseinhibitororblockingMRviaanMRinhibitor.Sincebothhypertensionandhyperaldosteronismspecificallyinducechronickidneydisease,inthismodel,wedemonstratedthatchronichigh-saltdietsinducedhypertensioninthismouselineandresultedinkidneyinflammationandinjury.BoththealdosteronesynthaseinhibitorandtheMRantonistmarkedlyblockedhigh-salt-diet-mediatedkidneyinjury.Thus,thistransgenicmouselinecanbeusedtostudythepathogenicmechanismsunderlyingaldosteroneanditsreceptorandtoscreentherapeuticcompoundsforaldosterone-mediatedhypertensionandrelatedcomplications,suchaskidneydisease,inhumans.Fullarticle(ThisarticlebelongstotheSpecialIssuePathogenicMechanismsofHypertensionandNeurodegenerativeDisorders)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5MoreArticles...OpenAccessJournalsAcousticsActaMicrobiologicaHellenica(AMH)ActuatorsAdministrativeSciencesAdolescentsAdvancesinRespiratoryMedicine(ARM)AerobiologyAerospacericultureriEngineeringrochemicalsronomyAIAirAlgorithmsAllergiesAlloysAnalyticaAnalyticsAnatomiaAnesthesiaResearchAnimalsAntibioticsAntibodiesAntioxidantsAppliedBiosciencesAppliedMechanicsAppliedMicrobiologyAppliedNanoAppliedSciencesAppliedSystemInnovation(ASI)AppliedChemAppliedMathAquacultureJournalArchitectureArthropodaArtsAstronomyAtmosphereAtomsAudiologyResearchAutomationAxiomsBactUn 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